Preparing High-Risk Patients with Hematologic Malignancies for Critical Care: A Pilot Study (PREP-ICU)
1Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada
2Intensive Care Unit, Sinai Health, Toronto, Ontario, Canada
3Department of Supportive Care, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada
J Crit Intensive Care - DOI: 10.14744/dcybd.2026.75378

Abstract

Aim: This study aimed to evaluate the feasibility, effectiveness, and acceptability of an intensive care unit (ICU) orientation intervention to improve advance care planning among patients with hematologic malignancies.
Study Design: This prospective observational cohort study enrolled high-risk hospitalized patients with hematologic malignancies who had a directive for full resuscitative measures. The intervention consisted of a: (1) video outlining ICU interventions and outcomes; (2) a values and preferences workbook; and (3) a follow-up meeting to discuss goals of care. Feasibility outcomes included recruitment and completion rates for each study component. Effectiveness was assessed using pre- and post-video surveys measuring knowledge of ICU interventions and outcomes. Acceptability was evaluated using an emotional impact survey and the proportion of participants who chose to terminate the video prematurely.
Results: Fifteen participants were recruited. Regarding feasibility, 11 of 15 participants (73%) completed all study components. All participants (15/15) completed the video, and 13 of 15 (87%) completed the follow-up meeting. Regarding effectiveness, the proportion of participants achieving a score of 90% or higher increased from the 8% (1/12) on the pre-video survey to 58% (7/12) on the post-video survey. Regarding acceptability, no participants terminated the video prematurely. Most participants reported being glad to have had the opportunity to discuss ICU-level care (11/12, 92%) and stated that they would recommend the video to others (10/12, 83%).
Conclusions: This pilot study provides important data to inform the development of a larger evaluation of an ICU orientation initiative aimed at promoting goal-concordant care in the event of critical illness.