ACTA Pharmaceutica Sciencia 2006 , Vol 48 , Num 2
MULTIPLE EMULSIONS OF FLURBIPROFEN - FORMULATION DEVELOPMENT AND EVALUATION
B MİSHRA, D THENNARASU, C SANKAR
Department of Pharmaceutics, IT, BHU, Varanasi - INDIA Multiple w/o/w and o/w/o emulsions of flurbiprofen were prepared and studied to see the effect of certain parameters like; gastro-intestinal pH of diffusion media, presence of polyvinylpyrrolidone in either internal or external phase, type of oil phase and presence of drug either internal or in both (external & internal) phases, on in vitro drug release. In vivo anti-inflammatory studies were also conducted in adult albino rats by measuring the decrease in carrageenin induced pedal oedema, through Plethismography. The release of Flurbiprofen was observed to be emulsion-type dependent. The various pH of the diffusion media reflected different release characteristics of drug from multiple emulsions. Incorporation of additive like polyvinylpyrrolidone, presence of drug either in internal phase or in both of the internal and external phases and the type of oil used in the preparation of multiple w/o/w and o/w/o emulsions significantly affected the drug release. Multiple w/o/w emulsion could provide maximum and controlled inhibition of pedal oedema in rats for prolonged periods in comparison to drug solution. Keywords : FLURBIPROFEN , MULTIPLE EMULSIONS, ADDITIVES, CONTROLLED DRUG RELEASE

Istanbul Medipol University