ACTA Pharmaceutica Sciencia 2006 , Vol 48 , Num 1
PHARMACOLOGICAL SCREENING OF ROOT OF OPERCULINA TURPETHUM AND ITS FORMULATIONS
RAJASHEKAR M BHANDE, LAAKSHMAYYA, PRAMOD KUMAR, NİTİN K MAHURKAR, S RAMACHANDRA SETTY
Department of Pharmacology, S.C.S. College of Pharmacy, Harapanahalli-India The root of Operculina turpethum is the chief ingredient in the Ayurvedic formulation viz. Avipattikara churna used for the treatment of gastric ulcer and related gastrointestinal disturbances. Its incorporation in the formulation is not scientifically studied. Hence, in the present study root and its formulations are investigated for anti-ulcer, anti-inflammatory and anti-diarrheal properties. The root powder of Operculina turpethum and its formulations were studied for anti-ulcer activity by using Shay rat that have administered preparation at 30 mg/kg and 100 mg/kg dose levels. The results revealed that the root powder and formulations have reduced the hyperacidity to the extent of 50 - 55% at 100mg/kg dose level. The root powder was found to be better than all formulations. The root powder and the formulation have reduced the charcoal movement significantly in charcoal meal test in mice at 400mg/kg dose. Similarly, these preparations have reduced the edema volume in formalin induced inflammation model in rats at 100mg/kg dose. The study revealed that the incorporation of root of Operculina turpethum in Avipattikara Churna is justifiable. Keywords : AVIPATTIKARA CHURNA, DIARRHEA, EDEMA VOLUME, HYPERACIDITY, OPERCULINA TURPETHUM, REDUCTION AND ULCER

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