ACTA Pharmaceutica Sciencia 2010 , Vol 52 , Num 2
CARBOXYMETHYLCELLULOSE - ALUMINUM HYDROGEL MICROBEADS FOR PROLONGED RELEASE OF SIMVASTATIN
RASHMİ BOPPANA, RAGHAVENDRA V KULKARNİ, CHİTRALİ MALLİKARJUN SETTY, NAVANATH V KALYANE
Department of Pharmaceutical Technology, BLDEA's College of Pharmacy, BLDE University, Bijapur, India Carboxymethylcellulose based hydrogel microbeads loaded with simvastatin were prepared using ionotropic gelation method. The beads were characterized by differential scanning calorimetric (DSC) analysis, and scanning electron microscopy (SEM). DSC studies confirmed the amorphous dispersion of the drug in the hydrogel matrix. The effect of crosslinking agent and polymer concentration on drug release was studied. Increase in concentration of crosslinking agent and polymers decreased the release rate of simvastatin. The release data were fitted to an empirical equation to determine the transport mechanism. Drug release followed anomalous/non-Fickian transport mechanism. Keywords : SIMVASTATIN, DRUG RELEASE, HYDROGEL BEADS, CARBOXYMETHYLCELLULOSE

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