ACTA Pharmaceutica Sciencia 2009 , Vol 51 , Num 3
EFFECT OF INTERACTING VARIABLES ON THE MECHANICAL AND RELEASE PROPERTIES OF CHLOROQUINE PHOSPHATE SUPPOSITORIES
The individual and interaction effects of type or nature of suppository base (N), concentration of surfactant (C), and storage (S) on the mechanical and release properties of chloroquine phosphate suppositories have been studied using a 23 factorial experimental design. Suppositories (1g) containing 100mg chloroquine phosphate each with or without 2%w/v Tween 20 as adjuvant, were prepared in Suppocire® AS2 and Witepsol® H15 bases. The mechanical properties of the suppositories were determined using crushing strength and dissolution properties were assessed using dissolution times (t50 and t80 - time for 50% and 80% drug release), and rates. The concentration of surfactant had the highest individual effect on the release properties of the suppository formulations while storage had the lowest effects. Thus, the type of suppository base and concentration of surfactant used in suppository formulations need to be carefully chosen in order to obtain suppositories of desired mechanical and drug release properties. Keywords : CHLOROQUINE, SUPPOSITORY BASE, SURFACTANT, VARIABLES, RELEASE PROPERTIES

Istanbul Medipol University