Journal of Medical and Surgical Intensive Care Medicine 2019 , Vol 10, Issue 1
Prognostic significance of critical patients’ platelet indexes in mixed type critical care unit
Serdar EFE 1 ,İsmail ASKER 1 ,Volkan İNAL 1
1Trakya Üniversitesi, İç Hastalıkları Yoğun Bakım, Edirne, Türkiye DOI : 10.33381/dcbybd.2019.1877 Introduction: Thrombocyte indexes (TIN) are biological markers of thrombocyte morphology and function. In critical patients, few studies evaluated TIN relation with disease severity and prognosis.

Aim: In this study, we objected to evaluate TIN as a routine feasible parameter at respect of clinical significance to predicting mortality, even though thrombocyte count and functions were prone to alter by variable conditions of critical care unit patients.

Materials and methods: Data of 314 patients those with objected parameters out of 347 retrospectively evaluated for TIN relation with clinical surveillance and demographics, in a ten bed capacity mixed-type tertiary CCU in between Jan 1st – 31st Dec 2016.

Results: Patients’, 194 male (62%), mean age was 62.7 ± 16.9 (19-86) and APACHE II score was 18.9 ± 8.5, mean length of stay (LOS) was 9.1 (1-182) days and with 43% mortality. The mean thrombocyte volume (MPV) and dispersion width (PDW) indexes were both correlated each other and positively with disease severity, on the other hand negatively with thrombocyte count. The higher plateletcrit (PCT) levels otherwise lower MPV and PDW were found in males, and also showed relatively lower mortality rates (37.6%<44.1%) (p<0.01). Increrased PDW levels and lower thrombocyte counts were related to higher mortality, in addition to this, PCT<0.17 levels showed 2x higher mortality risk compared to PCT>0.32. Both PDW/PLT and PDW/ PCT ratios related to mortality too (p<0.001, p<0.001), otherwise with relatively lower coefficients (r: 0,11, r: 0,10).

Conclusion: TIN in mixed type CCUs was assumed as PDW and PCT could be included to disease severity scoring system prognostic biomarkers, like thrombocyte counts. Keywords : Platelet indexes, mean platelet volume, platelet dispersion width, platelecrit