ACTA Pharmaceutica Sciencia 2011 , Vol 53 , Num 2
PHYSICOCHEMICAL CHARACTERIZATION OF RISPERIDONE SOLID DISPERSIONS
VENKATESKUMAR KRİSHNAMOORTHY, SUCHANDRA SEN, VERMA PRİYA RANJAN PRASAD
Department of Pharmaceutics, KMCH College of Pharmacy, Coimbatore, India Solid dispersions of risperidone in SSG were prepared by dispersion method and evaluated by phase solubility, in vitro, XRD, DSC, IR, particle size, NIR, Raman analysis, wetting and permeation studies. Phase solubility results proved the solubilization and spontaneity effect of carrier. The release rate from dispersions was higher than pure drug and it was found to increase with increase in carrier content. Based on release rate and dissolution parameters RSSG10 was found to be the best releasing dispersions in the lot. XRD, DSC, NIR and Raman analysis confirmed the crystallinity reduction in dispersions. IR analysis proved the compatibility between the drug and carrier. Particle size reduction was proved by the particle size analysis. Wettability and water absorption studies confirmed the increased wettability. The apparent permeability co-efficient of sample across the natural and synthetic membranes were found to better than pure drug. The possible mechanisms for high release rate from samples were postulated and it was well supported by characterization findings. Keywords : RISPERIDONE, DISSOLUTION EFFICIENCY, DISSOLUTION RATE CONSTANT, RELATIVE DISSOLUTION RATE, X-RAY DIFFRACTION, DIFFERENTIAL SCANNING CALORIMETRY

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